Effects of Sulphydryl Compounds on the Radiation Damage in Biologically Active DNA
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 37 (5) , 493-498
- https://doi.org/10.1080/09553008014550611
Abstract
The effect of sulfhydryl [SH] compounds on the induction [by .gamma.-rays] of alkali-labile sites and on the contribution of such sites to the inactivation of single-stranded [phage] .vphi.X174 DNA was studied. Cysteamine is capable of reacting with DNA radicals, thereby modifying the radiation damage in such a way that the induction of immediate and latent breaks is reduced. This depends on the pH of the solution. With only cysteine a pH dependent protection against lethal alkali-labile potential breaks could be observed. The damage other than breaks is not influenced by the presence of SH compounds.This publication has 15 references indexed in Scilit:
- Absorbed radiation dose from radionuclidic impurities in 99mTc obtained by different proceduresThe International Journal of Applied Radiation and Isotopes, 1974
- Deoxynucleotides—models for studying mechanisms of strand breakage in DNA—I protection by sulphydryl compoundsInternational Journal for Radiation Physics and Chemistry, 1971
- Chemical protection against breaks induced in DNA of human and bacterial cells by X-irradiationBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1970
- The structure of the DNA of bacteriophage φX174Journal of Molecular Biology, 1962
- Effect of Oxygen on the Radiosensitivity of Bacteriophage in the Presence of Sulphydryl CompoundsNature, 1960