CHEMICAL STRUCTURE OF JORO SPIDER TOXIN (JSTX)
Open Access
- 1 January 1987
- journal article
- research article
- Published by Biomedical Research Press in Biomedical Research
- Vol. 8 (4) , 241-245
- https://doi.org/10.2220/biomedres.8.241
Abstract
Toxic principles obtained from the venom of Joro spider (Nephila clavata) were purified with the reversed phase high performance liquid chromatography and four kinds of the major toxins (JSTX-1, -2, -3, and -4) were isolated. These principles commonly possessed 2,4-dihydroxyphenylacetyl-asparaginyl-cadaveryl moiety in the molecule. The structure of JSTX-3 was determined to be N-(2,4-dihydroxyphenylacetyl-L-asparaginyl)-N''-[N-[4-[(3-aminopropyl)amino]butyl].beta.-alanyl]cadaverine. The structure activity relationship of the spider toxin was discussed.This publication has 8 references indexed in Scilit:
- CHEMICAL CHARACTERIZATION OF SPIDER TOXIN, NSTX Biomedical Research, 1987
- Synthesis of spider toxin (JSTX-3) and its analogsTetrahedron Letters, 1987
- o-Phthalaldehyde—N-acetyl-L-cysteine as a chiral derivatization reagent for liquid chromatographic optical resolution of amino acid ernantiomers and its application to conventional amino acid analysisJournal of Chromatography A, 1986
- Chemical characterization of spider toxin, JSTX and NSTX.Proceedings of the Japan Academy, Series B, 1986
- Blockade of synaptic transmission in the squid giant synapse by a spider toxin (JSTX)Brain Research, 1983
- Spider venom contains specific receptor blocker of glutaminergic synapsesBrain Research, 1982
- Effect of a spider toxin on glutaminergic synapses in the mammalian brain Biomedical Research, 1982
- Putreanine, N-(4-Aminobutyl)-3-aminopropionic AcidPublished by Elsevier ,1969