Structure-Related Inhibiting Activity of Some Tobacco Cembranoids on the Prostaglandin Synthesisin vitro
- 1 August 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 59 (04) , 293-295
- https://doi.org/10.1055/s-2006-959684
Abstract
Structure-related inhibitory effects on the prostaglandin synthesis in vitro have been detected among eight diterpenoids of the cembrane class (1-8). The 4,6-diols 1 and 2 are the most active of the cembranoids studied with IC50 values of 0.36 and 0.39mM, respectively, as compared with an IC50 value of 1.4 for acetylsalicylic acid. Lower activities are found for cem-branoids having undergone oxidation of/at the 11,12 double bond (5-8), while the 4-hydroxy-6-oxocem-branoids 3 and 4 exhibit effects lower than those of 1 and 2 but higher than those of 5-8.Keywords
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