Persons at High Risk of Cancer

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Abstract
The remarkable family study of renal carcinoma reported in this issue of the Journal provides us with the first example of a dominantly inherited chromosomal aberration that imposes a high risk of a specific cancer. In this pedigree a translocation between chromosomes 3 and 8 is associated with an extraordinary risk of renal carcinoma. As in other familial cancers the median age of onset is considerably younger than for the general population and the tumor is often multifocal, with a probability that primary tumors will arise bilaterally that steadily increases with age. Each carrier of the genetic abnormality in the . . .

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