Kindlin-2 is required for myocyte elongation and is essential for myogenesis
Open Access
- 8 July 2008
- journal article
- Published by Springer Nature in BMC Cell Biology
- Vol. 9 (1) , 36
- https://doi.org/10.1186/1471-2121-9-36
Abstract
Integrins are required for normal muscle differentiation and disruptions in integrin signaling result in human muscle disease. The intracellular components that regulate integrin function during myogenesis are poorly understood. Unc-112 is an integrin-associated protein required for muscle development in C. elegans. To better understand the intracellular effectors of integrin signaling in muscle, we examined the mammalian homolog of Unc-112, kindlin-2.Keywords
This publication has 35 references indexed in Scilit:
- An X-Linked Myopathy with Postural Muscle Atrophy and Generalized Hypertrophy, Termed XMPMA, Is Caused by Mutations in FHL1American Journal of Human Genetics, 2008
- X-Linked Dominant Scapuloperoneal Myopathy Is Due to a Mutation in the Gene Encoding Four-and-a-Half-LIM Protein 1American Journal of Human Genetics, 2008
- Deletion of Integrin-Linked Kinase from Skeletal Muscles of Mice Resembles Muscular Dystrophy Due to α7β1-Integrin DeficiencyThe American Journal of Pathology, 2007
- Multifunctional roles of MT1-MMP in myofiber formation and morphostatic maintenance of skeletal muscleJournal of Cell Science, 2006
- Loss of FilaminC (FLNc) Results in Severe Defects in Myogenesis and Myotube StructureMolecular and Cellular Biology, 2006
- Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failureGenes & Development, 2006
- Integrin α3 subunit participates in myoblast adhesion and fusion in vitroDifferentiation, 2006
- PINCH, N(i)ck and the ILK: network wiring at cell–matrix adhesionsTrends in Cell Biology, 2005
- The
UNC-112
Gene in Caenorhabditis elegansEncodes a Novel Component of Cell–Matrix Adhesion Structures Required for Integrin Localization in the Muscle Cell MembraneThe Journal of cell biology, 2000
- α5 Integrin subunit expression changes during myogenesisBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1992