Inhibition of Gastric and Intestinal Motor Activity in Dogs by (Gln4) Neurotensin
- 1 June 1977
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 100 (2) , 231-235
- https://doi.org/10.1111/j.1748-1716.1977.tb05941.x
Abstract
The action of (Gln4)-neurotensin was studied on the spontaneous motor activity in isolated canine fundic, antral and intestinal pouches. All pouches had been prepared more than 6 months prior to the experiments. Spontaneous motor activity was recorded for at least 1 h before the (Gln4)-neurotensin was infused i.v. for 30 min in doses ranging between 6.3 and 100 ng × kg-1× min-1. In the vagally denervated fundic pouches (Gln4)-neurotensin inhibted motor activity in doses above 25 ng × kg-1× min-1. The vagally innervated antral pouches were more sentitive than the vagally denervated fundic pouches to the action of (Gln4)-neurotensin. Thus motor inhibition was induced by doses as low as 6.3 ng × kg-1× min-1. The effect of (Gln4)-neurotensin on motor activity in intestinal pouches was inconsistent. Inhibition was seen in 1 out of 7 expts. The present results show that the gastric motor activity is the most sensitive function to (Gln4)-neurotensin so far studied.This publication has 5 references indexed in Scilit:
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