Defining an epigenetic code
- 1 January 2007
- journal article
- Published by Springer Nature in Nature Cell Biology
- Vol. 9 (1) , 2-6
- https://doi.org/10.1038/ncb0107-2
Abstract
The nucleosome surface is decorated with an array of enzyme-catalysed modifications on histone tails. These modifications have well-defined roles in a variety of ongoing chromatin functions, often by acting as receptors for non-histone proteins, but their longer-term effects are less clear. Here, an attempt is made to define how histone modifications operate as part of a predictive and heritable epigenetic code that specifies patterns of gene expression through differentiation and development.Keywords
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