Asymmetric reduction of α-ketoesters with Hantzsch esters (dialkoxycarbonyldihydropyridines)
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 3,p. 101-102
- https://doi.org/10.1039/c39760000101
Abstract
Single and double asymmetric inductions were achieved by the reduction of pyruvates and benzoylformates with 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridine in the presence of a mono-ionised zinc species; differentiation is made between enantiotopic faces of the substrate carbonyl by diastereotopic hydrogen, and between diastereotopic faces by equivalent and diastereotopic hydrogen.Keywords
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