Application of the Lewis Acid Catalyzed [4+2]Cycloaddition Reaction to Synthesis of Natural Quinoline Alkaloids

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Abstract
Lewis acid catalyzed [4+2]cycloaddition reaction of the Schiff base with the olefin was applied to the syntheses of some natural quinoline alkaloids. The extension of [4+2]cycloaddition using the acetal and the orthoester as dienophiles or using s-triazine derivative as a Schiff base is also described. The electrocyclic reaction of the Schiff base was also examined to synthesize to quinoline compound.
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