Abnormal Serum Immunoglobulins Occurring With Reticular Neoplasms in an Inbred Strain of Mouse

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Abstract
The reticular neoplasms occurring spontaneously in SJL/J mice exhibit a broad spectrum which includes both pleomorphic and monomorphic tumors. The former can be divided into classes of histiocyte-predominant, plasmacyte-predominant, or mixtures of the two, the latter can be separated into pure reticulum cell sarcoma (type A) and lymphocytic neoplasia. Of the 50 tumors reported here, 33 were tested for abnormal serum proteins and 19 had discrete elevations in the immunoglobulin, or paraproteinemia. Of these 19 with paraprotein, 11 were γF, 4 were γH, 1 was γG, and 3 had 2 different paraproteins. Of the 16 attempted transplants, 12 grew successfully and 6 of these have apparently produced the same type of protein in transplant. The production of paraprotein and the progressive tumor growth resulting in death of the mouse are evidence for malignancy in a lesion which looks more hyperplastic than neoplastic. These tumors should provide a new model system for the study of the carcinogenic process and its relation to cellular differentiation as determined by the production of paraprotein.