The Effects of Immunosuppressive Drugs and Uremia on Automated Leukocyte Counts

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Abstract
Comparison between simultaneous Coulter S automatic leukocyte counts and hemocytometer counts revealed a significantly lower count by the first technic in patients receiving azathioprine and prednisone, and in uremic patients not receiving these drugs. No such difference was found in a group of control patients. It is suggested that the difference may be due to the destruction of abnormally fragile leukocytes as a result of the increased mechanical and chemical trauma of the Coulter S counting system.

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