Immune Monitoring of Surgical Colorectal Malignancies through Carcinoembryonic Antigen and Alpha-Fetoprotein Serum Levels, Flow-Cytometric Blood Lymphocyte Phenotyping and Tumor DNA Analysis
- 1 January 1997
- journal article
- research article
- Published by S. Karger AG in European Surgical Research
- Vol. 29 (6) , 465-472
- https://doi.org/10.1159/000129558
Abstract
67 patients with operable colorectal adenocarcinomas were divided into two groups based on criteria referring to DNA flow-cytometric models and the histopathological type and stage of intraoperatively harvested tumor samples: low-aggressive tumor group and highly aggressive tumor group. Two kinds of immunological markers were investigated: humoral (carcinoembryonic antigen and α-fetoprotein serum levels were measured by ELISA) and cellular (blood lymphocyte counts of the following subpopulations: CD3+, CD4+, CD8+/ CDllb+, CD19+, CD16+/CD56+, HLA-DR+/CD3+, measured by means of flow cytometry). All assays were similarly performed before and 2, 4, 6 and 8 weeks after tumor exeresis. Results seem to reveal a relationship between patients without immunological recovering and a bad postoperative clinical evolution of the highly aggressive colorectal malignant tumors. The significance of multiway immune monitoring of colorectal cancer is discussed.Keywords
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