Evaluation of the use of cyclodextrins in chiral separation of basic drug substances by capillary electrophoresis
- 1 January 1995
- Vol. 7 (4) , 219-225
- https://doi.org/10.1002/chir.530070407
Abstract
The influence of the choice of type and/or concentration of cyclodextrin, other additives, the temperature surrounding the capillary, and buffer pH on the separation of some chiral basic drug substances in capillary zone electrophoresis has been evaluated. It was found that pH of the buffer and type and concentration of cyclodextrin had a major influence on the separation.Keywords
This publication has 9 references indexed in Scilit:
- Practical aspects of chiral separations of pharmaceuticals by capillary electrophoresis I. Separation optimizationJournal of Chromatography A, 1994
- Systematic approach to treatment of enantiomeric separations in capillary electrophoresis and liquid chromatography.Journal of Chromatography A, 1994
- Separation of enantiomers by capillary electrophoretic techniquesJournal of Chromatography A, 1994
- Capillary zone electrophoresis for separation of drug enantiomers using cyclodextrins as chiral selectorsJournal of Chromatography A, 1994
- Macrocyclic Antibiotics as a New Class of Chiral Selectors for Liquid ChromatographyAnalytical Chemistry, 1994
- Capillary electrophoretic chiral separations using β-cyclodextrin as resolving agentJournal of Chromatography A, 1993
- Derivatized cyclodextrins immobilized on fused-silica capillaries for enantiomeric separations via capillary electrophoresis, gas chromatography, or supercritical fluid chromatographyAnalytical Chemistry, 1993
- Separation of Drug Stereoisomers by the Formation of β-Cyclodextrin Inclusion ComplexesScience, 1986
- 756. The optical resolution of aromatic amino-acids on paper chromatogramsJournal of the Chemical Society, 1952