Aggression, hyperactivity and platelet imipramine binding
- 1 September 1991
- journal article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 84 (3) , 209-211
- https://doi.org/10.1111/j.1600-0447.1991.tb03130.x
Abstract
We measured platelet 3H-imipramine binding parameters in 16 subjects affected by different types of mental deficiency, all characterized by hyperactive and/or aggressive behaviour, and in 16 healthy controls. The patients had a lower maximum binding capacity than the controls, with no difference in Kd, irrespectively of the type of mental disorder. These findings suggest a link between 5-HT disturbances, reflected by reduced imipramine binding sites, and behavioural dyscontrol, expressed as hyperactivity and aggression.Keywords
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