The Uptake of Orally Administered Trioleate-14C in Normal and Diabetic Rats with and without Butylbiguanide Application

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Abstract
Two hours after oral administration of triolein-14C the lipid-extractable radioactivity (LER) was measured in the gastrointestinal tract, the serum, the liver and in the adipose tissue of normal and diabetic rats with and without butylbiguanide application. The amount of LER was slightly less in the gastrointestinal tract of diabetic rats, indicating a somewhat increased fat absorption in diabetes although this difference was not significant. The strikingly high LER in the serum of diabetic rats demonstrated the well-known retention of exogenous fat in these animals, and also the liver and adipose tissue LER values were greater in diabetics than in controls. However, fat uptake from the circulation by the adipose tissue was significantly impaired in diabetes as was shown by the low adipose tissue LER/serum LER ratio. The s.c. injection of 100 mg/kg butylbiguanide simultaneously with the fat administration resulted in a significant reduction of fat absorption which was more pronounced in diabetic rats. Hence in the serum as well as in the liver and adipose tissue of all the rats, LER values were decreased by butylbiguanides. The calculated fat uptake by the adipose tissue, however, was improved in the butylbiguanide-treated animals. It seems that the effect of butylbiguanide on the fat-induced hyperlipemia results mainly from the diminished fat absorption, although an increased elimination of the fat by adipose tissue may also contribute to this effect.

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