COMPARISON OF I.M. LYSINE ACETYLSALICYLATE AND OXYCODONE IN THE TREATMENT OF PAIN AFTER OPERATION
Open Access
- 31 May 1980
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 52 (6) , 613-617
- https://doi.org/10.1093/bja/52.6.613
Abstract
Lysine acetylsalicylate (LAS) is a soluble salt of acetylsalicylic acid and can be given parenterally. LAS 12.5 mg kg−1 and 25 mg kg−1 were compared with oxycodone 0.15 mg kg−1 in the treatment of pain after operation in 60 patients undergoing varicose vein surgery. Both treatments almost completely relieved moderate to severe pain for the 3-h observation period. The time until the peak of action was longer after LAS (60–90 min) than after oxycodone (30–60 min). No significant differences were found between the smaller and larger doses of LAS, suggesting a plateau effect. Further clinical experiments with LAS using i.v. mode of administration and other pain models are warranted.This publication has 0 references indexed in Scilit: