Modifying role of vitamins on the mutagenic action of N-methyl-N'-nitro-N-nitrosoguanidine
- 31 December 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 9 (8) , 1513-1515
- https://doi.org/10.1093/carcin/9.8.1513
Abstract
Several vitamin compounds have been tested for their ability to suppress the mutagenicity of N-methyl-N''-nitro-N-nitrosoguanidine, a direct acting mutagen/carcinogen, in Salmonella typhimurium strain TA100. Menadione, .alpha.-tocopherol, retinal and retinol have displayed high inhibitory activity. The antimutagenic activity of menadione, in particular, has been found to be remarkable in as much as less than equimolar amount can reduce the mutagenic potency of the carcinogen by 50%. In vitro data suggest that its action is mediated by accelerating the deactivation of the N-nitroso carcinogen, possibly involving the formation of a quinone radical.This publication has 5 references indexed in Scilit:
- Inhibition of the mutagenicity and metabolism of 6-methyl-benzo[a]pyrene and 6-hydroxymethyl-benzo[a]pyreneBiochemical Pharmacology, 1986
- Vitamin K as a regulator of benzo(a)pyrene metabolism, mutagenesis, and carcinogenesis. Studies with rat microsomes and tumorigenesis in mice.Journal of Clinical Investigation, 1983
- Revised methods for the Salmonella mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1983
- Desmutagenic actions of ascorbic acid and cysteine on a new pyrole mutagen formed by the reaction between food additives; Sorbic acid and sodium nitriteBiochemical and Biophysical Research Communications, 1980
- MECHANISMS OF INHIBITION BY ASCORBATE OF MICROBIAL MUTAGENESIS INDUCED BY N-NITROSO COMPOUNDS1978