Emerging roles for lipids in shaping membrane-protein function
Top Cited Papers
- 20 May 2009
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 459 (7245) , 379-385
- https://doi.org/10.1038/nature08147
Abstract
Studies of membrane proteins have revealed a direct link between the lipid environment and the structure and function of some of these proteins. Although some of these effects involve specific chemical interactions between lipids and protein residues, many can be understood in terms of protein-induced perturbations to the membrane shape. The free-energy cost of such perturbations can be estimated quantitatively, and measurements of channel gating in model systems of membrane proteins with their lipid partners are now confirming predictions of simple models.Keywords
This publication has 62 references indexed in Scilit:
- Voltage-dependent K + channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membraneProceedings of the National Academy of Sciences, 2008
- Gating Mechanisms of Mechanosensitive Channels of Large Conductance, I: A Continuum Mechanics-Based Hierarchical FrameworkBiophysical Journal, 2008
- Macromolecular Crowding and Confinement: Biochemical, Biophysical, and Potential Physiological ConsequencesAnnual Review of Biophysics, 2008
- Protein area occupancy at the center of the red blood cell membraneProceedings of the National Academy of Sciences, 2008
- Protein modulation of lipids, and vice-versa, in membranesPublished by Elsevier ,2008
- Nav Channel Mechanosensitivity: Activation and Inactivation Accelerate Reversibly with StretchBiophysical Journal, 2007
- Cooperative Gating and Spatial Organization of Membrane Proteins through Elastic InteractionsPLoS Computational Biology, 2007
- Bilayer deformation by the Kv channel voltage sensor domain revealed by self-assembly simulationsProceedings of the National Academy of Sciences, 2007
- Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulationsProceedings of the National Academy of Sciences, 2006
- Lipids in the Structure, Folding, and Function of the KcsA K+ ChannelBiochemistry, 2002