PERSISTENCE OF LATERAL HYPOTHALAMIC-MEDIATED BEHAVIORS AFTER A SUPRALETHAL DOSE OF IONIZING-RADIATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 49  (7) , 868-873
Abstract
After exposure to 10 krad of high-energy electrons, rats experience an early transient incapacitation characterized by symptoms similar to those associated with lateral hypothalamic lesions: akinesia and decrements in various motivated behaviors. Experimenter-imposed electrical stimulation of the lateral hypothalamus in akinetic, irradiated animals produced a locomotor response similar to that seen in unexposed rats. Furthermore, when allowed to self-stimulate, the irradiated subjects persisted in vigorous self-stimulation of the lateral hypothalamus while self-stimulation rates of other subcortical sites showed marked attenuation. The lateral hypothalamus is apparently less sensitive to ionizing radiation than are the other subcortical structures sampled.

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