A Catalytic Asymmetric Michael Reaction of Silyl Enol Ethers with α,β-Unsaturated Ketones Using a Chiral Titanium Oxide
- 1 January 1994
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 23 (1) , 97-100
- https://doi.org/10.1246/cl.1994.97
Abstract
In the presence of a catalytic amount of [(R)-1,1′-bi-2-naphthalenediolato(2-)-O,O′]oxotitanium, silyl enol ethers of thioesters reacted with α,β-unsaturated ketones to afford the corresponding Michael adducts (1,5-dicarbonyl compounds) in high yields with moderate to high enantiomeric excesses.Keywords
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