PEDIATRIC TOTAL PARENTERAL-NUTRITION - LIVER HISTOPATHOLOGY

  • 1 January 1981
    • journal article
    • research article
    • Vol. 105  (3) , 152-156
Abstract
Correlation of clinical data with hepatic histopathology from 31 infants receiving total parenteral nutrition (TPN) suggests chronologic progression of liver disease with long-term TPN. Steatosis and a prominent eosinophil component in portal-tract extramedullary hematopoiesis appear during the first 5 days of TPN. The former persists for 90 days, the latter for 3 wk. Canalicular cholestasis was present after 10 days in 84.2% of the livers studied and bile duct proliferation in 63.6% after 3 wk of TPN. Moderate to severe portal fibrosis occurred after 90 days; micronodular cirrhosis developed in 1 patient after 5 mo. of TPN. Lipofuscin-like pigment and hemosiderin were demonstrated in 90.3% of the livers studied. With up to 90 days of TPN most changes should be reversible or not severe enough to result in liver failure.