Thorectandrols A and B, New Cytotoxic Sesterterpenes from the Marine Sponge Thorectandra Species
- 27 April 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 64 (5) , 661-663
- https://doi.org/10.1021/np000544e
Abstract
Two new sesterterpenes, thorectandrol A (1) and B (2), were isolated from extracts of the marine sponge Thorectandra sp. The structures were determined by extensive NMR spectral data analysis. NOE correlations were used to define the relative stereochemistry of 1 and 2, while CD data were used to suggest their absolute stereochemistry. Both compounds 1 and 2 inhibited the growth of MALME-3M (melanoma) and MCF-7 (breast) cancer cell lines in the range 30−40 μg/mL. The known compound palauolol (3) was isolated as well and was also cytotoxic.Keywords
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