Association of newly synthesized pro-opiomelanocortin with secretory granule membranes in pituitary pars intermedia cells

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Abstract
The prohormone, pro-opiomelanocortin (POMC) is synthesized on ribosomes, subsequently routed to the Golgi apparatus and finally packaged into secretory granules where it is processed to various biologically active hormones (α-melanotropin, adrenocorticotropin, β-endorphin and β-lipotropin). We report here that in frog and mouse pars intermedia cells, newly synthesized[3H]Arg-labeled POMC is associated with the secretory granule membrane prior to processing. This association with the secretory granule membrane may be related to the intracellular transport and packaging of POMC and/or the facilitation of processing of the prohormone within the organelle.