HOW MANY POLYMORPHIC GENES WILL IT TAKE TO SPAN THE HUMAN GENOME
- 1 January 1982
- journal article
- research article
- Vol. 34 (6) , 842-845
Abstract
It is desirable to know how many polymorphic marker loci will be required so that every human genetic locus can be mapped by classical pedigree methods to a specific region of a specific chromosome. Assuming a total autosomal map length of 33 morgans, it would take only about 33/(2 d [distance]) evenly spaced markers for every locus to be within d morgans of a marker. Taking into account that the markers will fall randomly along the genome, it is evident that a much larger number of such loci will have to be isolated and tested before the goal of a saturated gene map is reached.This publication has 7 references indexed in Scilit:
- A highly polymorphic locus in human DNA.Proceedings of the National Academy of Sciences, 1980
- Isolation and localization of DNA segments from specific human chromosomesProceedings of the National Academy of Sciences, 1980
- CONSTRUCTION OF A GENETIC-LINKAGE MAP IN MAN USING RESTRICTION FRAGMENT LENGTH POLYMORPHISMS1980
- DNA sequence variants in the Gγ-, Aγ-, δ- and β-globin genes of manCell, 1979
- Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.Proceedings of the National Academy of Sciences, 1978
- The prior probability of autosomal linkageAnnals of Human Genetics, 1975
- THE MAPPING OF HUMAN CHROMOSOMESAnnual Review of Genetics, 1971