HTO Oral Administration in Mice. I: Threshold Dose Rate for Haematopoietic Death

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Abstract
Tritiated water in various concentrations was orally administered continuously to (C57BL/6N and C3H/He)F1 female mice in a closed animal chamber. Tritium radioactivity in various organ tissues was measured periodically after initiating tritiated water intake using an automatic sample combustion system and a liquid scintillation counter. After 7 days the specific radioactivity reached a plateau. These data allowed absorbed organ doses to be estimated. Within a range of 1·48 × 1011 to 5·92 × 1011 Bq/dm3 as the concentration of tritiated water in drinking water, the time of death after initiating the administration was about 2 weeks, a typical time for haematopoietic death. A linear relationship of times of death with tritiated water concentrations in drinking water was observed, on a log-log scale, between 1·85 × 1010 Bq/dm3 and 1·48 × 1011 Bq/dm3. At concentrations lower than 9·25 × 109 Bq/dm3, mice no longer died from haematopoietic failure. We conclude, therefore, that there should be a threshold dose rate for haematopoietic death.