Cyclin E in human cancers
- 1 May 1999
- journal article
- review article
- Published by Wiley in The FASEB Journal
- Vol. 13 (8) , 773-780
- https://doi.org/10.1096/fasebj.13.8.773
Abstract
Regulators of the cell cycle such as cyclin E play an important part in neoplasia. The cyclin E protein forms a partnership with a specific protein kinase. This complex phosphorylates key substrates to initiate DNA synthesis. Cyclin-dependent kinase inhibitors (CKIs) are able to suppress the activity of cyclin E. Various substances (including proteins produced by oncogenic viruses) affect cyclin E directly or indirectly through an interaction with CKIs. These interactions are important in elucidating the mechanisms of neoplasia. They may also provide prognostic information in a wide range of common cancers. Cyclin E may even be a target for treatment of cancers in the future.—Donnellan, R., Chetty, R. Cyclin E in human cancers.Keywords
This publication has 95 references indexed in Scilit:
- Post-proliferative cyclin E-associated kinase activity in differentiated osteoblasts: Inhibition by proliferating osteoblasts and osteosarcoma cellsJournal of Cellular Biochemistry, 1997
- BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinasesOncogene, 1997
- A New Prognostic Strategy for Gastric CarcinomaAnnals of Surgery, 1997
- Reduced Expression of Cyclin–dependent Kinase Inhibitor p27Kipl Is Associated with Advanced Stage and Invasiveness of Gastric CarcinomasJapanese Journal of Cancer Research, 1997
- Cyclin E-induced S phase without activation of the pRb/E2F pathway.Genes & Development, 1997
- Altered Regulation of G1 Cyclins in Oxidant-induced Growth Arrest of Lung Alveolar Epithelial CellsPublished by Elsevier ,1996
- Different expression patterns of cyclins A, D1 and E in human colorectal cancerZeitschrift für Krebsforschung und Klinische Onkologie, 1996
- Interferon modulates the messenger RNA of G1-controlling genes to suppress the G1-to-S transition in Daudi cellsMolecular and Cellular Biochemistry, 1995
- Frequent Amplification of the Cyclin E Gene in Human Gastric CarcinomasJapanese Journal of Cancer Research, 1995
- Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)Cytogenetic and Genome Research, 1995