Comparative Analysis of Anti-Hepatitis C Virus Activity and Gene Expression Mediated by Alpha, Beta, and Gamma Interferons

Open Access

1 November 2002

journal article
research article
Published by American Society for Microbiology in Journal of Virology

Vol. 76 (21) , 11148-11154
https://doi.org/10.1128/jvi.76.21.11148-11154.2002

Abstract

A direct comparison of the inhibitory effects of alpha, beta, and gamma interferons (IFNs) on replication of a hepatitis C virus subgenomic replicon in a hepatoma cell line revealed similarities in antiviral potency. However, alternate IFN-induced antiviral mechanisms were suggested following observations of striking differences between IFN-γ and IFN-α/β with respect to strength and durability of the antiviral response and the magnitude and pattern of IFN-mediated gene expression.

Keywords

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