THE EFFECT OF PITUITARY GROWTH HORMONE ON THE LEVEL AND TURNOVER OF NUCLEIC ACIDS AND PHOSPHOLIPIDS OF THE RAT'S LIVER

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Abstract
SUMMARY: The levels of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), phospholipid and phosphoprotein and the turnover rates of DNA, nuclear and cytoplasmic RNA, and phospholipid, have been studied in the livers of rats treated with growth hormone for 12 hr or 3 days. There was no change in either the level or turnover of DNA. After a lag phase the level of RNA rose some 30% above control level and similar rises were noted in the turnover rate. The phospholipid content and turnover also increased as a result of the hormone treatment. There was a fall in the level of the phosphoprotein fraction. These results are discussed in relation to the increased rate of protein synthesis found in growth hormone-treated rats.

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