Quantitation of Ciprofloxacin Hydrochloride and Norfloxacin in Tablets Using High-Performance Liquid Chromatography

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Abstract
A stability-indicating high-performance liquid chromatography method for the quantitation of ciprofloxacin and norfloxacin in tablets (the only dosage form available at present) has been developed. The method is precise and accurate with a percent relative standard deviation based on 5 readings of 1.2 and 1.4 for ciprofloxacin and norfloxacin, respectively. A number of inactive ingredients present in the tablets did not interfere with the assay procedures. The addition of hydrochloric acid in the extraction procedure was necessary for the quantitative recovery and reproducible results. The recovery from the synthetic mixtures was quantitative. Both the drugs (quinolones) appear to be very stable since 10 minute boiling with either sulfuric acid or sodium hydroxide solution caused very little decomposition.

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