CONTROLLED TRIAL of INTRAVENOUS AMINOPHYLLINE IN ACUTE CEREBRAL INFARCTION

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Abstract
In a double-blind trial i.v. aminophylline was compared with placebo in 79 patients with acute cerebral infarction. Immediate improvement in the neurological evaluation score was significantly more frequent in patients receiving aminophylline (38%) than in those on placebo (15%); only patients with mild or moderately severe strokes responded to the injection. After 3 wk, the treated patients did not fare significantly better than the controls in terms of neurological score and residual disability. Survival rate, length of stay in hospital and social readaptation were similar in the 2 groups. I.v. aminophylline in patients with ischemic strokes can bring about an immediate symptomatic relief, but without appreciably influencing the ultimate recovery.