Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model
Open Access
- 1 December 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 46 (6) , 981-985
- https://doi.org/10.1093/jac/46.6.981
Abstract
Linezolid, a new oxazolidinone antibiotic, showed good penetration (38 ± 4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two iv injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally bactericidal at concentrations above the MIC (5 × and 10 × MIC).Keywords
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