Computer simulation of the slice profile in magnetic-resonance imaging

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Abstract
A computer simulation has been developed of the slice profile generated by the most commonly used pulse sequences in clinical imaging. This simulation enables a full description of the magnetisation vector to be made at any position across the slice at any time, both during and after the application of a pulse, to any desired accuracy. Presented here is an analysis of the most common pulse sequences: free-induction decay, inversion recovery, spin echo, saturation recovery and Carr-Purcell. The authors show preliminary results of the variation of slice profile with the key interpulse decay times for the first four of these sequences. Saturation recovery is shown to be the best choice of sequence for multiple-point T1 measurement as it presents the best compromise between slice profile artefacts and imaging time.

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