Long-Term Management of Acromegaly with Sandostatin
- 1 January 1988
- journal article
- Published by S. Karger AG in Hormone Research
- Vol. 29 (2-3) , 112-114
- https://doi.org/10.1159/000180983
Abstract
The present report illustrates the effectiveness of a long-acting somatostatin analog, SMS 201-995 (Sandostatin), in the chronic treatment of acromegaly. Daily doses of 50-300 micrograms were administered subcutaneously to 37 patients. Gradual dose increments induced a progressive GH decrease accompanied by a parallel reduction in plasma somatomedin C concentrations. There was a concomitant amelioration of clinical signs and symptoms throughout the investigational period. No escape phenomenon or tachyphylaxis was observed. It is concluded that chronic therapy with SMS 201-995 represents a promising medical alternative for the treatment of active acromegaly.Keywords
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