Commonly Used Medications that Interfere with Routine Endocrine Laboratory Procedures

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Abstract
Ten groups of commonly utilized medications were examined both in vitro and in vivo for their ability to interfere with optical density measurement and/or color development in such routine endocrine laboratory tests as those for 17-ketosteroids and 17-hydroxycorticosteroids. Certain antihypertensives, tranquilizers, psychic energizers, monoamine oxidase inhibitors, and soporifics were found to create the most problems in interference. The importance of removing these medications from the patients' therapeutic regimes prior to obtaining specimens for such endocrine procedures is stressed.