The Possible Significance of Hexosephosphoric Esters in Ossification

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Abstract
The author believes the data of his critics not necessarily in conflict with his own views. He Eoints out that while esterase is not necessary for calci-cation under the conditions of their experiments, he has nevertheless accumulated proof of its existence, and without it no inorganic phosphate could have occurred or been deposited in his own experiments. He repeats that this esterase is different from that of muscle, acting on a different substrate. Its presence in the intestinal mucosa may serve to hydrolyse certain phosphoric esters of the foodstuffs, and in the kidney for the excretion of inorganic phosphates. He believes retardation of calcification by presence of 1-2% of albumen to be due to the formation of an indiffusible calcium-protein compound, probably present normally in blood plasma.