The evolution of isochores
- 1 July 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 2 (7) , 549-555
- https://doi.org/10.1038/35080577
Abstract
One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.Keywords
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