A comment on the absence of calcium regulation of human thioredoxin reductase
- 8 November 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 334 (1) , 1-2
- https://doi.org/10.1016/0014-5793(93)81667-o
Abstract
It has been previously suggested that human thioredoxin reductase activity is regulated by calcium. However, the activity of a purified form of human placental thioredoxin reductase was found to not be affected by mM concentrations of calcium, well above intra- and extracellular physiological levels. Furthermore, the suggestion that an E-F hand is present in Escherichia coli thioredoxin reductase is strongly contested. These current results suggest that human thioredoxin reductase is not regulated by calciumKeywords
This publication has 10 references indexed in Scilit:
- Purification of human thioredoxin reductase: Properties and characterization by absorption and circular dichroism spectroscopyBiochemistry, 1993
- Characterization of the flavins and the iron-sulfur centers of glutamate synthase from Azospirillum brasilense by absorption, circular dichroism, and electron paramagnetic resonance spectroscopiesBiochemistry, 1992
- Thiordoxin regulates the DNA binding activity of NF-χB by reduction of a disulphid bond involving cysteine 62Nucleic Acids Research, 1992
- Thioredoxin reductase activity at the surface of human primary cutaneous melanomas and their surrounding skinInternational Journal of Cancer, 1991
- A Genetic Tool Used to Identify Thioredoxin as a Mediator of a Growth Inhibitory SignalScience, 1991
- EF-hands calcium binding regulates the thioredoxin reductase/thioredoxin electron transfer in human keratinocytesBiochemical and Biophysical Research Communications, 1989
- Calcium regulates thioredoxin reductase in human metastatic melanomaBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1989
- The activity and purification of membrane-associated thioredoxin reductase from human metastatic melanotic melanomaBiochimica et Biophysica Acta (BBA) - General Subjects, 1988
- THIOREDOXINAnnual Review of Biochemistry, 1985
- Rat liver thioredoxin and thioredoxin reductase: purification and characterizationBiochemistry, 1982