Presenilin 2 regulates the systolic function of heart by modulating Ca2+signaling

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Abstract
SPECIFIC AIMSMutations in presenilin 2 (PS2) genes account for early-onset Alzheimer’s disease, and PS2 is ubiquitously expressed in various tissues including hearts. In this study, we examined cardiac phenotypes of PS2 knockout (PS2KO) mice in order to elucidate a role of PS2 in hearts.PRINCIPAL FINDINGS1. Physiological characteristics of PS2KO heartsThe PS2KO hearts showed no evidence of any cardiac morphologic defects, nor did histological examination of the hearts demonstrate any myofibrillar disarray, necrosis, or ventricular fibrosis. There was no significant difference in the myocyte cross-sectional area of PS2KO and wild-type littermate (WT) mice (201.1±8.6 μm2 for WT and 200.5±3.5 μm2 for PS2KO). Nor were there any differences in the ratios of heart weight to body weight (4.09±0.07 mg/g for WT and 4.18±0.04 mg/g for PS2KO) and left ventricular (LV) weight to body weight (2.97±0.07 mg/g for WT and 3.11±0.04 mg/g for PS2KO) between PS2KO and WT hearts. Hemodynamic data did not indicate any differen...
Funding Information
  • Ministry of Education, Culture, Sports, Science and Technology (16590683)