Multiple sexual partners and mother-to-child transmission of HIV-1

Publisher Website
Google Scholar
Abstract
Objective: To investigate risk factors for mother-to-child transmission of HIV-1, particularly sexual behavior before and during pregnancy. Design and methods: This study is part of a prospective cohort study in Butare, Rwanda, of 318 HIV-1-seropositive and 309 HIV-1-seronegative women enrolled during pregnancy and followed for a mean duration of 21 months (range, 8–34 months). Clinical follow-up of the mother–infant pairs was performed at 6-week intervals during the first year of life and at 4-month intervals thereafter. Detailed sexual history interviews were conducted during pregnancy and at the first postnatal visit. Results: Of 184 singleton infants born to HIV-1-infected mothers who survived the neonatal period, 32 (17%) children were classified as HIV-1-infected, 130 (71%) as not infected, and 22 (12%) died with indeterminate HIV-1 infection status. The vertical transmission rate was estimated to be between 20 and 29%. Unprotected sexual intercourse with increased number of partners during the past 5 years was strongly associated with mother-to-child transmission (P7:1639–1645

This publication has 0 references indexed in Scilit: