A Factor That Can be Used to Regulate an In Vitro Primary Immune Response
- 1 March 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 69 (3) , 594-598
- https://doi.org/10.1073/pnas.69.3.594
Abstract
A factor has been isolated that supports the stimulation of an immune response against heterologous erythrocyte antigens in mouse spleen cells cultured in a medium that contains deficient serum. The factor is secreted by certain spleen cells that are obtained in permanent culture after leukemia virus infection. The factor permits antigen-sensitive cells derived from bone marrow to mature to antibody-forming cells. This factor can be used in controlling the initiation of a primary immune response in vitro .Keywords
This publication has 18 references indexed in Scilit:
- The structure and assembly of murine leukemia virus: Intracellular viral RNAVirology, 1971
- The Third Cell Type Required for the Immune Response of Spleen Cells in vitroThe Journal of Immunology, 1971
- Immune Response Restoration with Macrophage Culture SupernatantsScience, 1971
- Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl SulfoxideProceedings of the National Academy of Sciences, 1971
- Cell components in the immune response: II. Cell attachment separation of immune cellsCellular Immunology, 1970
- Cell components in the immune responseCellular Immunology, 1970
- IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICEThe Journal of Experimental Medicine, 1967
- Immunocompetence of Transferred Thymus-Marrow Cell CombinationsThe Journal of Immunology, 1966
- Long-Term Propagation of the Rauscher Murine Leukemia Virus in Tissue Culture2JNCI Journal of the National Cancer Institute, 1965
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951