Influence of pH on Toxicity of Vanadium in Mice

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Abstract
In an effort to elucidate the mode of detoxication of V and of antidotal action of ascorbic acid for V (to be published), lethal doses of NaVO3.H2O and NH4VO3 were admn. to mice that had been previously given sufficient amts. of NH4CI or NaHCO3 to alter HCO3 reserve. All injns. were intraperit. NH4CI (400 mg./kg.) reduced mortality ratios to 25% from an original 60% caused by NaVO3.H2O alone (10.9 mg. V/kg.). NaHCO3, 2 g./kg. contrariwise increased mortality ratios to 80% from the 40% caused by NaVO3.H2O (9.1 mg. V/kg.). The LD85 dose of NaVO3. H2O injd. at pH 7 was reduced to essentially zero (no mortality) by prior lowering of the injected NaVO3.H2O soln. to pH 1.8. Increasing the pH of the NaVO3.H2O soln. to 12.5 did not increase the toxicity for mice at the level injd. (9.1 mg. V/kg.). Accordingly, one of the means by which V may be detoxified in the body appears to be acidification.

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