Parameters of mortality in human populations with widely varying life spans
- 1 July 1983
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 2 (3) , 373-380
- https://doi.org/10.1002/sim.4780020309
Abstract
A three‐component, competing‐risk mortality model, developed for animal survival data, fits human life table data for all ages over a range of mean life spans from 16 to 74 years. The competing risks are a novel exponentially‐decreasing hazard, dominant during immaturity; a constant hazard, dominant during adulthood; and an exponentially increasing Gompertzian hazard, dominant during senescence. By fitting the model to a specific life table using non‐linear techniques, estimates of the five model parameters and their standard errors obtain; the proportion of deaths expected from each hazard alone may then be calculated. Preliminary analysis of 13 life tables indicates that for human populations under heavy stress, with very short mean life spans of about 20 years, the three hazard components account for roughly equal numbers of deaths; for modern populations, with mean life spans of about 75 years, nearly all deaths are due to the hazard of senescence. Factor analysis of the correlation matrix of parameter values for the 13 populations shows a two‐factor structure. One factor involves only the multiplicative constants (initial values) of the three hazards, but not the hazard rates of change; the second factor involves only the parameters of the immaturity hazard and the rate of acceleration of the senescence hazard, but not the constant hazard nor the multiplicative constant (initial value) of the senescence hazard.Keywords
This publication has 19 references indexed in Scilit:
- A function minimization computer package (MFIT) for nonlinear parameter estimation providing readily accessible maximum likelihood estimatesComputers and Biomedical Research, 1978
- The Weibull Distribution: A New Method of Summarizing Survivorship DataEcology, 1978
- Simple Regression Methods for Survival Time StudiesJournal of the American Statistical Association, 1973
- A model to account for mortality curves of various speciesJournal of Theoretical Biology, 1970
- Nature's Time-scale: Degenerative Disease in ManNature, 1967
- A REPETITIVE ANALOG COMPUTER FOR ANALYSIS OF SUMS OF DISTRIBUTION FUNCTIONSAnnals of the New York Academy of Sciences, 1964
- Redundancy and Biological AgingScience, 1963
- The Stochastic Theory of Mortality*Annals of the New York Academy of Sciences, 1962
- Experimental Studies on the Duration of Life. XIV. The Comparative Mortality of Certain Lower OrganismsThe Quarterly Review of Biology, 1935
- VI. An estimate of the degrees of the mortality of mankind; drawn from curious tables of the births and funerals at the city of Breslaw; with an attempt to ascertain the price of annuities upon livesPhilosophical Transactions of the Royal Society of London, 1693