Echogenic substantia nigra in patients with orthostatic tremor
- 3 November 2004
- journal article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 112 (7) , 915-920
- https://doi.org/10.1007/s00702-004-0236-6
Abstract
Objectives: Previous studies suggest that the nigrostriatal dopaminergic transmission is impaired in patients with primary orthostatic tremor. Methods: We used transcranial sonography (TCS) to examine the morphology of the substantia nigra (SN) in four patients with primary orthostatic tremor (OT). Results: TCS revealed an SN echogenicity in all patients, in three patients unilaterally, in one patient bilaterally. Conclusions: Our data suggest nigrostriatal dopaminergic deficits in OT patients. The exact impact of these dopaminergic deficits on OT generation is unclear.Keywords
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