Autoimmunity and the highway to diabetes
- 1 February 1997
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 75 (1) , 1-6
- https://doi.org/10.1038/icb.1997.1
Abstract
Summary Insulin-dependent diabetes mellitus (IDDM) is an immunopathological condition involving loss of cell function, but views of how this arises are confusing and contradictory. For example, studies with non-obese diabetic mice implicate abnormal cytokine production in disease pathogenesis, but give little insight into how this arises. Many genetic and environmental risk factors have been described, but no single factor predicts the development of disease. Moreover, the prevalence of auto-antibodies suggests an autoimmune aetiology, but no antigen is recognized by all individuals. As an aid to understanding how IDDM develops, this review considers the risk factors as distinct starting points on a journey, and reviews current literature in search of the point where the roads from each origin merge into a highway to diabetes.Keywords
This publication has 47 references indexed in Scilit:
- The genetics of the NOD mouseDiabetes/Metabolism Research and Reviews, 1995
- Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.Journal of Clinical Investigation, 1995
- Induction of diabetes in standard mice by immunization with the p277 peptide of a 60‐kDa heat shock proteinEuropean Journal of Immunology, 1995
- mRNAs can be stabilized by DEAD-box proteinsNature, 1994
- Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic MouseClinical Immunology and Immunopathology, 1994
- Interference by a Non-Interferon-Inducing Subvariant of Benign Encephalomyocarditis Virus-B with the Ability of EMCV-D to Produce Insulin-Dependent Diabetes Mellitus in ICR Swiss Male MiceJournal of Interferon Research, 1993
- MHC-Linked Diabetogenic Gene of the NOD Mouse: Molecular Mapping of the 3′ Boundary of the Diabetogenic RegionBiochemical and Biophysical Research Communications, 1993
- Glucocorticoids in the nonobese diabetic (NOD) mouse: Basal serum levels, effect of endocrine manipulation and immobilization stressLife Sciences, 1992
- Correlation between islet cell antibodies and anti-cytomegalovirus IgM and IgG antibodies in healthy first-degree relatives of type 1 (insulin-dependent) diabetic patientsClinical Immunology and Immunopathology, 1990
- Effect of coxsackievirus B4 infection in mice on expression of 64,000-Mr autoantigen and glucose sensitivity of islets before development of hyperglycemiaDiabetes, 1988