Induction of heme oxygenase 1 in liver of spontaneously diabetic rats
- 1 January 2001
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research
- Vol. 34 (2) , 189-191
- https://doi.org/10.1080/10715760100300171
Abstract
It has been suggested that diabetes induces an increase in oxidative stress; the increased expression of heme-oxygenase 1 (HO-1) in liver is believed to be a sensitive marker of the stress response. The aim of this study was to examine whether diabetes is able to induce HO-1 expression in liver. The specific mRNA was amplified by RT/PCR and calibrated with amplified β-actin mRNA. The mRNA HO-1 levels in the liver of spontaneously diabetic rats were increased by 1.8 fold compared with non diabetics; this supports the hypothesis of weak but significant oxidative damage due to chronic hyperglycaemia. This work represents the first in vivo study exploring the semi-quantitative expression of HO-1 in the liver of spontaneously diabetic rats.Keywords
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