Libraries from libraries: Generation and comparison of screening profiles
- 1 October 1996
- journal article
- research article
- Published by Springer Nature in Molecular Diversity
- Vol. 2 (1-2) , 41-45
- https://doi.org/10.1007/bf01718699
Abstract
A positional scanning tetrapeptide library was chemically modified through alkylation and/or reduction of the amide bonds, thus generating three new combinatorial libraries with physico-chemical properties very different from the parent peptide library (‘libraries from libraries’). Specific results were obtained with each of these libraries upon screening in κ-opioid receptor binding and microdilution antimicrobial assays, illustrating the potential of the ‘libraries from libraries’ concept for the efficient generation of a variety of chemically diverse combinatorial libraries.Keywords
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