New Metabolizable Immunologic Adjuvant for Human Use. 6. Disposition of Radioactivity after Administration of Labelled Vaccine To the Rat

Publisher Website
Google Scholar
Abstract
Emulsions prepared with Adjuvant 65 have been shown effective immunologically, but less irritating than those containing mineral oil. This report demonstrates that the fatty components of an Adjuvant 65 vaccine were absorbed and were dis-posed of by normal metabolic processes. Three batches of Adjuvant 65 were prepared, each labelled with C14 in one of the components, and emulsified with aqueous suspensions of killed influenza virus. The vaccines were administered intramuscularly to rats, and the disposition of the tracer was followed for 120 days. C14 from aluminum monostearate-1-C14 and from Arlacel A (mannide-l-C14-monooleate) disappeared from the injection site more rapidly than C14 from peanut oil (oil containing a small excess of glyceryltrioleate added as carboxyl-C14-labelled triglyceride). Expiration of C1402 from injected aluminum stearate or labelled peanut oil vaccines snows that these fatty materials reached the metabolic pools and were metabolized normally. C14 injected as mannide-labelled Arlacel A did not accumulate in the tissues, most of it being excreted via the urine.

This publication has 2 references indexed in Scilit: