Mechanisms for Ovariectomy-Induced Hyperalgesia and Its Relief by Calcitonin: Participation of 5-HT1A-Like Receptor on C-Afferent Terminals in Substantia Gelatinosa of the Rat Spinal Cord
- 15 August 2000
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 20 (16) , 6302-6308
- https://doi.org/10.1523/jneurosci.20-16-06302.2000
Abstract
Chronic treatment with calcitonin in osteoporotic patients alleviates the pain associated with this condition by an unknown mechanism. In ovariectomized rats that develop osteoporosis and hyperalgesia, we examined whether a functional change in serotonergic systems in the spinal dorsal horn was involved, using whole-cell recordings from substantia gelatinosa neurons in spinal cord slices and [3H]8-hydroxy-2(di-n-propylamino)tetralin ([3H]8-OH-DPAT) binding. Hyperalgesia could be attributed to the elimination of presynaptic inhibition by 5-HT of glutamatergic primary C-afferent terminals and an associated decrease in the density of [3H]8-OH-DPAT binding sites whose receptors are neither 5-HT1A- nor 5-HT7-subtype. These changes in serotonergic systems were restored after chronic treatment with calcitonin. Reversal of 5-HT receptor changes by calcitonin treatment may provide an explanation for its analgesic actions in patients.Keywords
This publication has 41 references indexed in Scilit:
- The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranesPublished by Elsevier ,2003
- Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cordThe Journal of Physiology, 1999
- Ovariectomy-Induced Hyperalgesia and Antinociceptive Effect of Elcatonin, a Synthetic Eel CalcitoninPharmacology Biochemistry and Behavior, 1998
- Effect of elcatonin on involutional osteoporosisJournal of Bone and Mineral Metabolism, 1996
- Gene regulation by steroid hormonesCell, 1989
- Central Projections of Identified, Unmyelinated (C) Afferent Fibers Innervating Mammalian SkinScience, 1986
- Antinociceptive activity of salmon calcitonin injected intrathecally in the ratNeuroscience Letters, 1984
- Morphological features of functionally defined neurons in the marginal zone and substantia gelatinosa of the spinal dorsal hornJournal of Comparative Neurology, 1979
- Reexamination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibersJournal of Comparative Neurology, 1979
- Effects of intracerebroventricular calcitonin in the conscious rabbitCellular and Molecular Life Sciences, 1975