Symptomatic Epstein-Barr virus infection and multiple sclerosis.

Open Access

1 February 1993

journal article
research article
Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry

Vol. 56 (2) , 167-168
https://doi.org/10.1136/jnnp.56.2.167

Abstract

In a case-control study of 214 patients with multiple sclerosis, recall of infectious mononucleosis in subjects seropositive for Epstein-Barr viral capsid antigen was associated with a relative risk of 2.9 (95% CI 1.1 to 7.2). Those who reported having infectious mononucleosis before the age of 18 years had a relative risk of multiple sclerosis of 7.9 (95% CI 1.7 to 37.9). The pathogenesis of multiple sclerosis may involve an age-dependent host response to Epstein-Barr virus infection.

Keywords

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