Antisickling Activity of Hydroxybenzoic Acids inCajanus cajan
- 1 August 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 58 (04) , 317-320
- https://doi.org/10.1055/s-2006-961475
Abstract
The amounts of phenylalanine and hydroxybenzoic acid in a Cajanus cajan methanolic extract were estimated. Results showed that the amount of phenylalanine and hydroxybenzoic acid per gram weight of bean was 4.92 mg ± 0.13 mg and 21.0 mg ± 3.0 µg, respectively. Sickling inhibition was observed to be efficient with the extract which contains a mixture of phenylalanine (0.69 mg/ml) and p-hydroxybenzoic acid (10.5 µg/ml), equivalent to those found in bean extract. The additive antisickling effect of both compounds can be therapeutically exploited for the treatment of sickle cell anemia.Keywords
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